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Can Melatonin Help Manage Seizures in Epileptic Dogs?

Updated: Jun 14

Can Melatonin Help Manage Seizures in Epileptic Dogs?

What is Melatonin?

Melatonin is a hormone produced primarily by the pineal gland in the brain. It plays a crucial role in regulating the body's circadian rhythms, which govern the sleep-wake cycle and other biological processes. But can melatonin help manage seizures in epileptic dogs? Melatonin has also been found to possess potent antioxidant and neuroprotective properties, making it an intriguing potential therapeutic agent for various neurological conditions, including epilepsy.

Melatonin's Antioxidant and Neuroprotective Effects

According to research, melatonin has been shown to have significant antioxidant and anti-inflammatory effects in the central nervous system. During a seizure, the brain experiences oxidative stress and inflammation, which can contribute to neuronal damage. Melatonin's ability to neutralize free radicals and reduce inflammation may help protect the brain and potentially reduce the severity or frequency of seizures. Additionally, melatonin has been found to modulate neurotransmitter systems involved in seizure generation and propagation, such as GABA and glutamate. By regulating these neurotransmitters, melatonin may help stabilise neuronal excitability and prevent seizure activity.


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Research on Melatonin and Seizure Management

While research on the use of melatonin for seizure management in dogs is still limited, several studies have explored its potential benefits in both animal models and human patients.

Animal Studies

In a study by Yildirim et al., intraventricular administration of melatonin in rats with penicillin-induced epilepsy resulted in a significant dose-related reduction in seizure frequency compared to the control group. Similar findings were reported by Mevissen and Ebert, who demonstrated that melatonin increased the electroconvulsive threshold and suppressed generalised seizures in an amygdala stimulation model.

Human Studies

In a review by Jain and Besag, the authors analysed 26 previously published studies on the relationship between melatonin and epileptic seizures. While the results were mixed, most studies suggested a possible link between melatonin supplementation and a reduction in seizure frequency or severity. One study by Molina-Carballo et al. found that serum melatonin levels increased significantly during seizures in children with convulsive epilepsy and febrile seizures. This led to the hypothesis that the body may stimulate melatonin production as a response to abnormal brain activity during seizures.

Potential Benefits and Considerations

In addition to its potential anti-seizure effects, melatonin may offer other benefits for dogs with epilepsy, such as improved sleep quality and regulation of circadian rhythms. There is also some research that suggests melatonin can work in the management of anxiety and other behavioural challenges. However, it's important to note that melatonin should not be used as a sole treatment for canine epilepsy and should be considered as a complementary therapy alongside prescribed anti-seizure medications and under the guidance of a veterinarian.


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Potential Reactions

Melatonin is often used as a supplement to help dogs with anxiety, sleep disorders, and certain medical conditions, but it can have some negative effects.

  1. Drowsiness: One of the most common side effects, as melatonin can cause excessive sleepiness or lethargy, especially if given in higher doses.

  2. Digestive Issues: Some dogs may experience gastrointestinal problems such as vomiting, diarrhea, or stomach cramps.

  3. Hormonal Imbalances: Melatonin can affect hormone levels. It may interfere with reproductive hormones, potentially affecting breeding dogs or dogs with hormonal disorders.

  4. Changes in Blood Sugar: Melatonin can affect insulin and blood sugar levels, making it risky for diabetic dogs.

  5. Increased Heart Rate: In some cases, melatonin can cause an increased heart rate or palpitations.

  6. Allergic Reactions: Though rare, some dogs might have an allergic reaction to melatonin, leading to symptoms like itching, swelling, or difficulty breathing.

  7. Interactions with Other Medications: Melatonin can interact with other medications, particularly those affecting the central nervous system, and can either amplify or reduce their effectiveness.

Consulting with Your Veterinarian

If you're considering introducing melatonin to your dog's treatment plan, it's crucial to consult with your veterinarian first. They can evaluate your dog's specific condition, discuss potential risks and benefits, and provide guidance on appropriate dosages and administration.

It's also important to remember that melatonin, like any supplement or medication, may interact with other drugs or have side effects. Your veterinarian can help monitor your dog's response and make any necessary adjustments to ensure their safety and well-being.

Conclusion: Can Melatonin Help Manage Seizures in Epileptic Dogs?

While more research is needed to fully understand the role of melatonin in managing canine epilepsy, this natural supplement may offer a promising complementary approach for some dogs. By working closely with your veterinarian and exploring all available treatment options, you can help improve your dog's quality of life and provide them with the best possible care.


Vasileva, Z. (2021). Melatonin and epilepsy. Folia Medica, 63(6), 827-833.

Yildirim, M., & Marangoz, C. (2004). Anticonvulsant effects of melatonin on epileptiform activity in rats with kainic acid-induced epilepsy. Neurological Sciences, 25(6), 337-342.

Mevissen, M., & Ebert, U. (1998). Anticonvulsant effects of melatonin in amygdala-kindled rats. Neuroscience Letters, 257(1), 13-16.

Jain, S. V., & Besag, F. M. (2013). Does melatonin affect epileptic seizures?. Drug Safety, 36(4), 281-286.

Molina-Carballo, A., et al. (2007). Melatonin's role in mediating seizures described in the Bible. Revista de Neurologia, 45(7), 410-414.

Landsberg, G. M. (2014, May). Principles of pharmacologic and natural treatment for behavioral problems. Merck Manual Veterinary Manual: Professional Version., Retrieved October 16, 2022, from

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